While the "Download Latest Patches" button handles this automatically, users can create their own .pnach files if they know the specific memory addresses (offsets) they wish to modify. This requires reverse engineering skills and knowledge of the game's memory structure.
I notice you’re asking about a “cheat manager” for the (PlayStation 3 emulator). cheat manager rpcs3
Disabling native anti-aliasing or motion blur that causes black screens when upscaling. While the "Download Latest Patches" button handles this