One of the major themes explored in "Sons and Daughters" is the conflict between tradition and modernity. De Graft skillfully portrays the inner turmoil experienced by characters as they navigate the challenges of a rapidly changing world. The play also examines the roles of men and women in traditional African society, shedding light on issues of power, authority, and social responsibility. Through the characters of Agorsah and Amponsem, de Graft masterfully illustrates the complexities of human relationships and the consequences of one's actions.