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Research published in Nature Communications indicates that specific stromal lipid species, such as phosphatidylcholine, dictate melanoma metastasis by creating "hot" metabolic environments that enhance mitochondrial activity. The study highlights that cells within these environments show distinct tropism, with certain lipids promoting lung colonization while others, like ceramide, favor liver metastasis. Read the full study at PubMed Central (PMC) (.gov) haldi 2024 fugi original hot

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