You must use a Powered USB Hub . This is a hub that plugs into a wall outlet. The hub provides the power to the Radium 49, rather than the computer doing the heavy lifting. This resolves 90% of connection issues with vintage USB gear.
Most DAWs allow MIDI Learn. Map the Radium’s knobs/sliders manually to parameters. Limitation: The device sends raw MIDI CCs; without the driver, the mapping is not persistent across all software. m-audio radium 49 driver mac
Here is everything you need to know about M-Audio Radium 49 drivers for Mac, from official legacy support to modern workarounds. Official Driver Compatibility (Legacy Systems) You must use a Powered USB Hub
macOS Catalina (10.15) and newer (including Ventura and Sonoma). Apple Discussions Recommended Workarounds without the driver