Absolutely. Resident Evil 4 on PPSSPP for Android, even with a highly compressed ISO, remains one of the most satisfying mobile gaming experiences. The tank controls feel surprisingly natural with touch-screen overlays, and pairing a Bluetooth controller (like a PS4 or Xbox pad) makes it almost indistinguishable from a console experience.
Go to PPSSPP Settings → Graphics → Rendering Mode → Change from "Buffered Rendering" to "Non-buffered rendering." This fixes 90% of RE4 graphical glitches.
: Users sometimes confuse PPSSPP with AetherSX2 (a PlayStation 2 emulator for Android). You can play the actual Resident Evil 4 on Android using the AetherSX2 or NetherSX2 emulators with a PS2 ISO file.