Directly? No. There is no native .app file or official macOS port for Sonic P-06. The game is built using the Unity engine for Windows (DirectX).
: A separate project called "Sonic 06 Marathon Recompiled" has shown footage of a native macOS version in development, which aims to bring the original Xbox 360 experience to modern systems. How to Run P-06 on Mac sonic p-06 mac download
Whisky is a modern, free wrapper for Apple’s Game Porting Toolkit that works well on M1/M2/M3 chips. : Follow the on-screen setup to install required scripts. Create a Bottle : Set the Windows version to Windows 11 Install Fonts Directly