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While NTFS works, FAT32 is the most compatible format for both Wii and GameCube (Nintendont) homebrew.
Wii USB loaders are notoriously picky. High-quality USB 3.0/3.1 sticks or external Hard Drives (HDDs/SSDs) provide the most stable experience. Conclusion wbfs files wii repack
The WBFS format strips out this unnecessary padding, leaving only the playable game data. This compression can shrink a 4.7 GB game down to under 1 GB in some cases (for example, New Super Mario Bros. Wii is roughly 350 MB when scrubbed). While NTFS works, FAT32 is the most compatible