Prioritizes pre-operative chemotherapy to shrink the tumor and reduce the risk of intraoperative rupture, followed by surgery. Standard Stages: Stage I: Limited to the kidney; completely excised.
Associated genes: WT1 (11p13), WT2 (11p15), CTNNB1 , and TP53 . wilms tumor ppt new
Loss of heterozygosity (LOH) at chromosomes 1p and 16q is now used as a prognostic marker to identify patients at higher risk of relapse. completely excised. Associated genes: WT1 (11p13)