If you install the raw Build 19041.1 ISO without allowing Windows Update to run, you will encounter several bugs that Microsoft fixed in later cumulative updates (like KB4550945, KB4566803). Noteworthy issues:
Connecting or disconnecting a Thunderbolt docking station while the system was sleeping could trigger a CRITICAL STRUCTURE CORRUPTION BSOD. Fixed via later patches. Windows 10 Insider Preview Build 19041 ISO